Our research is centered around molecular programming, using nucleic acid-based nanotechnology to engineer three-dimensional structures. Our nanostructures serve as a foundation to precisely functionalize living organisms. Through the fusion of nucleic acid-based nanotechnology and genetic engineering, our research seeks to unlock avenues for designing living organisms with sophisticated signal-processing capabilities.

The inherent programmability of nucleic acids makes them a suitable candidate for engineering biological systems with tailored and dynamic functionalities. Our approach employs in silico design to optimize nucleic acid-based nanostructures, focusing on dynamic reconfiguration, enhanced cell uptake, and live cell imaging. We fine-tune design parameters using computational simulations, ensuring efficient performance. Characterization involves gel electrophoresis and atomic force microscopy to assess assembly efficiency and physical attributes. Live cell imaging reveals interactions with cells, aiding in understanding cellular responses and behavior. This comprehensive methodology enhances the development of functional nanotechnologies with applications in imaging and drug delivery.